2 the genetic basis of cancer
The genetic basis of type 2 diabetes in a multi ethnic population in singapore
Ngày tải lên :
14/09/2015, 08:48
... impact of a family history of diabetes; to further assess the genetic basis of type diabetes, we next examine the contribution of recently identified novel T2DM susceptibility loci on the risk of ... environmental factors) are most likely the cause of familial aggregation of diseases 7.3 THE COMPLEXITY OF THE GENETICS OF TYPE DIABETES Genetic studies of diseases have traditionally relied on two ... use of linkage analysis in genetic studies of rare, monogenic forms of diabetes, such as maturity-onset diabetes of the young (MODY) have been relatively successful in identifying the aberrant genetic...
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báo cáo khoa học: " Genetic mapping of wild introgressions into cultivated peanut: a way toward enlarging the genetic basis of a recent allotetraploid" docx
Ngày tải lên :
12/08/2014, 03:21
... introgression of a small fraction of the wild genome species while keeping the genetic background of the cultivated is a good mean to explore the largely untapped reservoir of useful alleles of interest ... application of molecular breeding approaches for the genetic improvement of cultivated peanut Up to date, few genetic linkage maps have been published in Arachis At the diploid level, three genetic ... due to the low level of polymorphism between cultivated peanut varieties, QTLs have been detected attesting of the interest of molecular breeding tools in genetic improvement of peanut Burow et...
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Elucidating the genetic basis of severe obesity learning from the experiments of nature
Ngày tải lên :
11/09/2015, 09:02
... GENETIC BASIS OF SEVERE OBESITY: LEARNING FROM THE EXPERIMENTS OF NATURE DR LEE YUNG SENG MBBS, MMED (PAED MED), MRCP (UK), MRCPCH, FAMS A THESIS SUBMITTED FOR THE DEGREE OF PH.D DEPARTMENT OF ... of Cys28Phe and Leu37Phe 92 B) Co-segregation of C28F and L37F with overweight/obesity in 93 families 4-3 Structure of POMC and location of mutations 95 4-4 Sequence alignment of N-terminus of ... genes of this cohort were screened by direct sequencing The POMC gene of more than 900 DNA samples from the Genetics of Obesity Study (GOOS) (Cambridge, UK) were screened using a combination of...
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THE MOLECULAR BASIS OF PLANT GENETIC DIVERSITY pdf
Ngày tải lên :
28/06/2014, 11:20
... Preface The purpose of The Molecular Basis of Plant Genetic Diversity is to provide a glimpse into the dynamic process of genetic variation by presenting the thoughts of some of the scientists ... detection of genetic variation/diversity has greatly enhanced studies of evolution There is The Molecular Basis of Plant Genetic Diversity no doubt that genetic variation influences the fitness of individuals, ... genes of value for plant improvement Furthermore, knowledge of population structure of genetic resources is necessary for the development of strategies for appropriate conservation of genetic...
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Báo cáo sinh học: "The complex genetic basis of simple behavio" ppt
Ngày tải lên :
06/08/2014, 19:21
... reflect the effects of large numbers of genetic variants of relatively small effect and, therefore, that genetic dissection of such traits will require investigation of samples of considerable size ... important form of corroboration of the role of a given gene in contributing to complex behavioral traits Demonstrations of the importance of pleiotropy in the genetic regulation of behavioral ... that a universal feature of complex behavior may be the contribution of numerous genetic variants of small effect may influence experimental design in human genetic studies of behavioral traits Furthermore,...
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Báo cáo y học: "The molecular basis of lung cancer: molecular abnormalities and therapeutic implications" potx
Ngày tải lên :
12/08/2014, 18:21
... Tissue microarrays (TMAs) of lung cancer Tissue microarrays (TMAs) of lung cancer TMAs are comprised of core biopsies of 0.6 mm in diameter of different tumors and of uninvolved lung from the ... exposure of the whole airway mucosa to tobacco smoke could cause the entire bronchial tree to be at increased risk of developing lung cancer, leading to the concept of field cancerization Field cancerization ... non-small cell lung cancer [47] An increased number of marker chromosomes were observed in patients having a higher number of packs of cigarettes smoked over years Epigenetic alterations of gene expression...
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Tài liệu The Electrical Properties of Cancer Cells pptx
Ngày tải lên :
14/02/2014, 22:20
... properties of cancer cells part • Some of the characteristic features of cancerous cells that affect their electrical activity are: Cancer cells are less efficient in their production of cellular ... more depth • One of the characteristic features of injured and cancerous cells is that they are less efficient in their production of cellular energy (ATP) One of the mysteries of cancer is whether ... potential of cancer cells, the concentration of sodium and potassium inside of cancer cells, and the mechanisms that cancer cells use to produce energy Cure has proposed that the accumulation of an...
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Tài liệu PROTEOMIC APPLICATIONS FOR THE EARLY DETECTION OF CANCER doc
Ngày tải lên :
15/02/2014, 05:20
... online to: Cancer. gov: http://www .cancer. gov /cancer_ information/ bladder cancer | breast cancer | colon cancer | liver cancer | lung cancer | oesophageal cancer | ovarian cancer | prostate cancer ... 70% (107 of 153) of sera from patients with benign disease and PSA levels of >4 ng/ml, and could accurately predict the presence of cancer in 95% of the patients tested, including 18 of 21 men ... this type of technology to the clinic detection and to the problem of ovarian cancer diagnosis53 More than two-thirds of ovarian cancer cases are detected at advanced stages, when the cancer cells...
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GENOMIC DISORDERS The Genomic Basis of Disease doc
Ngày tải lên :
05/03/2014, 23:20
... (3) elucidation of the chemical basis of heredity, the molecular basis of disease has been addressed in the context of how mutations affect the structure, function, or regulation of a gene or its ... analysis of the human genome has enabled detection of genome changes heretofore not observed because of technology limitations Whereas agarose gel electrophoresis enables detection of changes of the ... BEAUDET, MD • Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX WEIMIN BI, PhD • Department of Molecular and Human Genetics, Baylor College of Medicine, Houston,...
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The Gale encyclopedia of cancer pdf
Ngày tải lên :
06/03/2014, 18:20
... medium blue) Each of these regions may be affected by cancer, and the cancers include: Nasopharyngeal cancer; Oropharyngeal cancer; Esophageal cancer; and Laryngeal cancer Oral cancers can affect ... GALE ENCYCLOPEDIA of Cancer The GALE ENCYCLOPEDIA of Cancer A GUIDE TO CANCER AND ITS TREATMENTS VO L U M E A-K E L L E N T H A C K E R Y, E D I T O R The GALE ENCYCLOPEDIA of CANCER STAFF Ellen ... treatments, cancer side effects, and cancer drugs In addition, entries have been included to facilitate understanding of common cancer- related concepts, such as cancer biology, carcinogenesis, and cancer...
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The Gale encyclopedia of cancer pptx
Ngày tải lên :
06/03/2014, 18:20
... Li-Fraumeni syndrome Age of onset for cancers associated with Li-Fraumeni syndrome Age of onset Type of cancer Infancy Development of adrenocortical carcinoma Development of soft-tissue sarcomas Acute ... frequency of lip cancer is often lumped together with oral cancer, although lip cancer is probably much more like skin cancer in origin There are about 30,000 new diagnoses of mouth and lip cancer ... 75% of cases of primary liver cancers are HCC) In Africa and Asia, over 40 persons in 200,000 will develop this form of cancer (more than 90% of cases of primary liver are HCC) Two rare types of...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
Ngày tải lên :
17/03/2014, 17:20
... contribution of spontaneous NADPH oxidation and other reductases in the samples can be ignored One unit of GR activity was defined as the amount of enzyme that catalyzes the oxidation of lmol of NADPH ... W.R & York, J.L (1996) Differential expression of glutathione S-transferase isoforms in compartments of the testis and segments of the epididymis of the rat Drug Metab Dispos 24, 725–733 Ó FEBS ... system of adult rats (A) Enzymatic activities of 90 lg cytosolic proteins from five organs and spermatozoa of 13-week-oldrats were measured in a 1-mL cuvette Data are presented as the means ± SD of...
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The Biological Basis of Nursing: Clinical Observations ppt
Ngày tải lên :
22/03/2014, 22:20
... aldosterone action The natural history of bilirubin Physiology of defecation Stimulation of the vomit centre Vestibular stimulation of the cerebellum Vagus innervation of the digestive tract Oesophageal ... integral part of, has a biological focus, often in the form of drugs or surgery Nurses today, as clinical specialists, are taking on more advanced work, often in areas previously thought of as being ... result of different growth stages in children may affect the use of the infrared probe and therefore the accuracy of this type of thermometer This may be one reason why tympanic measurements of temperature...
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OECD Environment Working Papers No. 2: The Health Costs of Inaction with Respect to Air Pollution potx
Ngày tải lên :
23/03/2014, 00:20
... the Cost of Inaction will be published in late 2008 It represents the views of the author and does not necessarily reflect the official views of the Organisation or of the governments of its member ... terms of “burden of disease” The burden of disease is measured in terms of the disabilityadjusted life year (DALY), a summary measure encompassing the impact of premature death (i.e the number of ... premature deaths (i.e 1.2% of global deaths) and 6.4 million years of life lost (i.e 0.5% of total years of life lost) per year (Cohen et al., 2005) Given the importance of health impacts associated...
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Báo cáo khoa học: The structural basis of calpain behavior pptx
Ngày tải lên :
23/03/2014, 10:21
... structural basis of calpain behavior Y Benyamin two parts, DIIa and DIIb, come closer together, with concomitant release of constraints between the domains (large arrows) This active conformation of ... and oscillations of [Ca2+], in particular those involving specific phosphorylations of calpastatin, calpains and targets The following Minireviews develop three themes on the role of calpain and ... Elce JS, Davies PL & Jia Z (1999) Crystal structure of calpain reveals the structural basis for Ca2+dependent protease activity and a novel mode of enzyme activation EMBO J 18, 6880–6889 Strobl...
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Báo cáo khoa học: "The Linguistic Basis of a Mechanical Thesaurus " doc
Ngày tải lên :
23/03/2014, 13:20
... generalization of a comparative grammar (i.e a non-linguistic abstraction from the description of a finite number of languages ) avoids the necessity of the comparative (source-target) identification of ... determining features of all forms in Language 2, and document two has shown us what forms of Language can be predicted with what probability to be the translation equivalents of what forms of Language ... output of the translation process is thus a result of three processes, in two of which the two languages impinge upon one another First we have translation equivalence, second, equivalence of determining...
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Breakaway: The global burden of cancer— challenges and opportunities pot
Ngày tải lên :
28/03/2014, 23:20
... Appendix C An overview of the spectrum of cancer control Breakaway: The global burden of cancer challenges and opportunities Appendix C An overview of the spectrum of cancer control Cancer control refers ... a sum of US$305bn for the total economic burden of new cancer cases in 2009 Costs of new cancer cases by cancer site and cost component, 2009 Direct Costs Cancer site Total Bladder Brain Cancers ... economic burden of cancer Overview A key objective of this report is an exploration of the global burden of cancer in demographic and economic terms, including the distribution of new cancer cases...
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Báo cáo khoa học: The molecular basis of heme oxygenase deficiency in the pcd1 mutant of pea pot
Ngày tải lên :
30/03/2014, 11:20
... Lineweaver–Burk plots Modelling the structure of PsHO1 A three-dimensional model of the structure of pea HO was produced on the basis of the alignment of its amino acid sequence (minus the N-terminal ... last nucleotides of the exons, respectively (C) Phylogenetic tree of plant HO-like sequences The protein sequence for the mature region of PsHO1 was aligned with mature sequences of previously identified ... region of Arabidopsis thaliana HO1 (AtHO1) and was used as the basis for the design of gene specific primers The 5¢- and 3¢-ends of the pea HO1 cDNA were obtained by rapid amplification of cDNA...
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A gene expression database for the molecular pharmacology of cancer pptx
Ngày tải lên :
30/03/2014, 13:20
... colon cancer COLO 205; CNS cancer SNB-19; melanoma LOX-IMVI; ovarian cancers OVCAR-3 and OVCAR–4; renal cancer CAKI-1; prostate cancer PC-3; and breast cancers MCF7 and HS 578T nature genetics ... degree of similarity between cell clustering on the basis of drugs and on the basis of genes, we derived a ‘correlation of correlation’ parameter r as follows: let Uij denote the correlation of cells ... selected on the basis of its pharmaceutical significance, not on the basis of its correlation, the statistical multiple comparisons problem does not involve all of the hundreds of thousands of correlations...
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